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CVT-313

A potent and selective inhibitor of CDK2 (cyclin dependent kinase 2)
Catalog #: B1137
SKU-Size Size Price Qty
B1137-5 5 mg
$95.00
B1137-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name 2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine
Appearance White Solid
CAS # 199986-75-9
Molecular Formula C₂₀H₂₈N₆O₃
Molecular Weight 400.48
Purity ≥98% by HPLC
Solubility DMSO (> 10 mg/ml)
SMILES CC(C)N1C=NC2=C1N=C(N=C2NCC3=CC=C(C=C3)OC)N(CCO)CCO
InChi 1S/C20H28N6O3/c1-14(2)26-13-22-17-18(21-12-15-4-6-16(29-3)7-5-15)23-20(24-19(17)26)25(8-10-27)9-11-28/h4-7,13-14,27-28H,8-12H2,1-3H3,(H,21,23,24)
InChi Key NQVIIUBWMBHLOZ-UHFFFAOYSA-N
PubChem CID 6918386
MDL Number MFCD06411412
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CVT-313 is a potent and selective inhibitor of CDK2 (cyclin dependent kinase 2) arresting cell growth with IC₅₀ ranging from 1.25 to 20 µM. The Inhibition is competitive with respect to ATP (Ki = 95 nM). CVT-313 has no effect on other, nonrelated ATP-dependent serine/threonine kinases. 


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