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CVT-10216

A potent and selective ALDH2 inhibitor
Catalog #: B2765
SKU-Size Size Price Qty
B2765-1 1 mg
$75.00
B2765-5 5 mg
$265.00
More Sizes Get Quote

Product Details

Alternate Name CVT10216; 3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]benzoic acid; GS-455534
Peptide Sequence N/A
Appearance Off-white solid
CAS # 1005334-57-5
Molecular Formula C₂₄H₁₉NO₇S
Molecular Weight 465.48
Purity ≥98% by HPLC
Solubility >40 mg/ml DMSO
SMILES CS(=O)(=O)NC1=CC=C(C=C1)C2=COC3=C(C2=O)C=CC(=C3)OCC4=CC(=CC=C4)C(=O)O
InChi InChI=1S/C24H19NO7S/c1-33(29,30)25-18-7-5-16(6-8-18)21-14-32-22-12-19(9-10-20(22)23(21)26)31-13-15-3-2-4-17(11-15)24(27)28/h2-12,14,25H,13H2,1H3,(H,27,28)
InChi Key YYOOFJZTRCPVFD-UHFFFAOYSA-N
PubChem CID 23661666
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CVT-10216 is a potent, selective, and reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). CVT-10216 has been reported to reduce excessive alcohol drinking in alcohol-preferring rats and to prevent self-administration of alcohol in Long-Evans rats.


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