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Curcumin, Curcuma longa (High Purity)

A potent antioxidant
Catalog #: 1850
SKU-Size Size Price Qty
1850-10 10 mg
$60.00
1850-50 50 mg
$185.00
More Sizes Get Quote

Product Details

Alternate Name 1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane
Appearance Orange-yellow solid
CAS # 458-37-7
Molecular Formula C₂₁H₂₀O₆
Molecular Weight 368.38
Purity ≥98%
Solubility DMSO (25 mg/ml) or EtOH (10 mg/ml)
SMILES COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
InChi InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
InChi Key VFLDPWHFBUODDF-FCXRPNKRSA-N
PubChem CID 969516
MDL Number MFCD00008365
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. An antioxidant and dual inhibitor of 5-lipoxygenase (IC₅₀ = 8 µM) and cyclooxygenase (COX) (IC₅₀ = 52 µM). Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Also shown to be a p300/CREB-binding protein-specific inhibitor of histone acetyltransferase, inhibiting the acetylation of histones H3 and H4 with an IC₅₀ of ~25 µM. Does not affect p300/CREB binding protein-associated factor (PCAF).


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