Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

CUR-61414

A potent Hedgehog signaling pathway inhibitor
Catalog #: 2743
SKU-Size Size Price Qty
2743-5 5 mg
$125.00
2743-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name N-[(3S,5S)-1-(1,3-Benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethylbutanamide
Appearance Tan solid
CAS # 334998-36-6
Molecular Formula C₃₁H₄₂N₄O₅
Molecular Weight 550.69
Purity ≥98% by TLC
Solubility DMSO (40 mg/ml) or EtOH (20 mg/ml)
SMILES CC(C)(C)CC(=O)N(CC1=CC(=CC=C1)OC)C2CC(N(C2)CC3=CC4=C(C=C3)OCO4)C(=O)N5CCNCC5
InChi InChI=1S/C31H42N4O5/c1-31(2,3)17-29(36)35(19-22-6-5-7-25(14-22)38-4)24-16-26(30(37)33-12-10-32-11-13-33)34(20-24)18-23-8-9-27-28(15-23)40-21-39-27/h5-9,14-15,24,26,32H,10-13,16-21H2,1-4H3
InChi Key WPHXYKUPFJRJDK-UHFFFAOYSA-N
PubChem CID 9829015
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CUR-61414 is a potent, cell-permeable , Hedgehog signaling pathway inhibitor (IC₅₀ = 100-200 nM). Selectively binds to Smo but not other GPCRs. CUR 61414 blocks proliferation and induces apoptosis in mouse basal cell carcinoma and causes regression of basaloid lesions triggered by ultraviolet light in mouse skin.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.