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A potent Hedgehog signaling pathway inhibitor
Catalog #: 2743
SKU-Size Size Price Qty
2743-5 5 mg
2743-25 25 mg
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Product Details

Alternate Name N-[(3S,5S)-1-(1,3-Benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethylbutanamide
Appearance Tan solid
CAS # 334998-36-6
Molecular Formula C₃₁H₄₂N₄O₅
Molecular Weight 550.69
Purity ≥98% by TLC
Solubility DMSO (40 mg/ml) or EtOH (20 mg/ml)
InChi InChI=1S/C31H42N4O5/c1-31(2,3)17-29(36)35(19-22-6-5-7-25(14-22)38-4)24-16-26(30(37)33-12-10-32-11-13-33)34(20-24)18-23-8-9-27-28(15-23)40-21-39-27/h5-9,14-15,24,26,32H,10-13,16-21H2,1-4H3
PubChem CID 9829015
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


CUR-61414 is a potent, cell-permeable , Hedgehog signaling pathway inhibitor (IC₅₀ = 100-200 nM). Selectively binds to Smo but not other GPCRs. CUR 61414 blocks proliferation and induces apoptosis in mouse basal cell carcinoma and causes regression of basaloid lesions triggered by ultraviolet light in mouse skin.

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