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CUDC-101

A potent inhibitor of HDACs and receptor tyrosine kinases
Catalog #: 1966
SKU-Size Size Price Qty
1966-5 5 mg
$140.00
1966-25 25 mg
$465.00
More Sizes Get Quote

Product Details

Alternate Name 7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide
Appearance White solid
CAS # 1012054-59-9
Molecular Formula C₂₄H₂₆N₄O₄
Molecular Weight 434.49
Purity ≥98% by HPLC
Solubility DMSO
SMILES COC1=C(C=C2C(=C1)N=CN=C2NC3=CC=CC(=C3)C#C)OCCCCCCC(=O)NO
InChi InChI=1S/C24H26N4O4/c1-3-17-9-8-10-18(13-17)27-24-19-14-22(21(31-2)15-20(19)25-16-26-24)32-12-7-5-4-6-11-23(29)28-30/h1,8-10,13-16,30H,4-7,11-12H2,2H3,(H,28,29)(H,25,26,27)
InChi Key PLIVFNIUGLLCEK-UHFFFAOYSA-N
PubChem CID 24756910
MDL Number MFCD15528940
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC₅₀ values of 4.4, 2.4, and 15.7 nM, respectively. Displays potent antiproliferative and proapoptotic activities against cultured and implanted tumor cells that are sensitive or resistant to several approved single-targeted drugs.


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