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Cathepsin B, mouse recombinant

An anti-protease implicated in myoclonus epilepsy.
Catalog #: P1095

In stock

$125.00

Product Details

Cat # +Size P1095-10
Size 10 μg
Alternate Name Cathepsin B, Ctsb, CB
Gene Symbol Ctsb
Gene ID 13030
Accession # P10605
Source Insect cell (Baculovirus)
Appearance Liquid
Physical Form Description In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol
Molecular Weight 36.4 kDa
Purity by SDS-PAGE ≥90%
Endotoxin Level < 1 EU/μg
Biological Activity Specific activity is >2,000 pmol/min/ug and is defined as the amount of enzyme that hydrolyze 1pmole of Z-Arg-Arg-AMC to Z-Arg-Arg and AMC per minute at pH 6.0 at 37C.
Amino Acid Sequence HDKPSFHPLS DDLINYINKQ NTTWQAGRNF YNVDISYLKK LCGTVLGGPK LPGRVAFGED IDLPETFDAR EQWSNCPTIG QIRDQGSCGS CWAFGAVEAI SDRTCIHTNG RVNVEVSAED LLTCCGIQCG DGCNGGYPSG AWSFWTKKGL VSGGVYNSHV GCLPYTIPPC EHHVNGSRPP CTGEGDTPRC NKSCEAGYSP SYKEDKHFGY TSYSVSNSVK EIMAEIYKNG PV
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

CTSB, also known as cathepsin B preproprotein, is a papain-family cysteine protease that is normally located in lysosomes. It has the ability to degrade several extracellular matrix components at both neutral and acidic pH and has been implicated in the progression of several human and rodent tumors progression and arthritis. Recombinant mouse CTSB, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.


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