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Anti-CTLA4 Antibody

Rabbit polyclonal unconjugated antibody to detect CTLA4 in human samples
Catalog #: A1083
$155.00

Product Details

Cat # +Size A1083-100
Size 100 µl
Antibody Target CTLA4
Alternate Name Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CTLA4, CD152
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen KLH conjugated synthetic peptide between 50-78 amino acids from the N-terminal region of human IDDM12.
Accession # P16410
Gene ID 1493
Appearance Colorless liquid
Formulation PBS with 0.09% (W/V) sodium azide
Purification Protein A column, followed by peptide affinity purification.
Species Reactivity Human
Application WB, IHC-P
Positive Control WB
Application & Usage WB: 1:2000IHC-P: 1:50~100
Handling The antibody solution should be gently mixed before use
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.


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