Product Details
| Cat # +Size | A1083-100 |
|---|---|
| Size | 100 µl |
| Antibody Target | CTLA4 |
| Alternate Name | Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, CTLA4, CD152 |
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | KLH conjugated synthetic peptide between 50-78 amino acids from the N-terminal region of human IDDM12. |
| Accession # | P16410 |
| Gene ID | 1493 |
| Appearance | Colorless liquid |
| Formulation | PBS with 0.09% (W/V) sodium azide |
| Purification | Protein A column, followed by peptide affinity purification. |
| Species Reactivity | Human |
| Application | WB, IHC-P |
| Positive Control | WB |
| Application & Usage | WB: 1:2000IHC-P: 1:50~100 |
| Handling | The antibody solution should be gently mixed before use |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
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