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Product Details
| Alternate Name | Connective Tissue Growth Factor, CCN2, Hypertrophic chondrocyte-specific protein 24 (HCS24), Insulin-like growth factor-binding protein 8 |
|---|---|
| Gene Symbol | CTGF |
| Gene ID | 1490 |
| Accession # | NM_001901 |
| Source | E. coli |
| Appearance | Lyophilized protein |
| Physical Form Description | Sterile filtered and lyophilized with no additives |
| Molecular Weight | 11.2 kDa |
| Purity by SDS-PAGE | ≥95% |
| Purity by | ≥95% |
| Endotoxin Level | <0.1 ng/μg |
| Biological Activity | ED₅₀ 1.0–2.0 μg/ml determined by the dose-dependent stimulation of the proliferation of HUVEC cells. |
| Reconstitution Instructions | Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| USAGE | For Research Use Only! Not to be used in humans |
Details
CTGF is a member of the CCN family of secreted cysteine rich regulatory proteins and is the major mitogenic and chemoattractant protein produced by μmbilical vein and Vascular endothelial cells. CTGF stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial, and epithelial cells, and binds to IGF, TGF β1, and BMP-4. Cell migration and adhesion are signaled through binding to specific cell surface integrins and to heparin sulfate proteoglycans CTGF (98 a.a.), a lower molecular weight isoform containing the C-terminal portion of the full length CTGF protein, exerts full heparin binding, cell adhesion, and mitogenic CTGF activity. Recombinant human CTGF is a 11.2 kDa protein of 98 amino acid residues.
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