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CSTB, human recombinant

An anti-protease implicated in myoclonus epilepsy.
Catalog #: 9235
SKU-Size Size Price Qty
9235-10 10 µg
$120.00
9235-25 25 µg
$365.00
More Sizes Get Quote

Product Details

Alternate Name Cystatin-B, Stefin B, PME, CST6
Gene Symbol CSTB
Gene ID 1476
Accession # NP_000091
Source E.coli
Appearance Liquid
Physical Form Description Liquid
Molecular Weight This protein is fused with a 6× His tag at N-terminus and has a calculated MW of 13 kDa.
Purity by SDS-PAGE >95%
Purity by >95%
Biological Activity IC50 value is < 3nM
Reconstitution Instructions In 20 mM Tris-HCl buffer (pH8.0) containing 50mM NaCl.
Amino Acid Sequence MGSSHHHHHH SSGLVPRGSH MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG TNYFIKVHVG DEDFVHLRVF QSLPHENKPL TLSNYQTNKA KHDELTYF
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

CSTB, also known as Cystatin B is an anti-protease implicated in myoclonus epilepsy, a degenerative disease of the central nervous system. The cystatin superfamily encompasses proteins that contain multiple cystatin like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. This protein is able to form a dimer stabilized by noncovalent forces and is thought to play a role in protecting against the proteases leaking from lysosomes. In cells, CSTB is located in the lysosomes and the cytoplasm, but also in the nucleus.


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