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CSK, Active

Phosphorylates human Src
Catalog #: 7722
$295.00

Product Details

Cat # +Size 7722-5
Size 5 μg
Alternate Name CSK, C-src tyrosine kinase, Protein-tyrosine kinase CYL
Gene Symbol CSK
Gene ID 1445
Accession # NM_004383
Source Baculovirus (Sf9 insect cells)
Appearance Lyophilized powder
Physical Form Description Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 0.5 mM PMSF, pH 7.4, 5% trehalose and 5% mannitol.
Molecular Weight 78.0 kDa
Purity by SDS-PAGE ≥85%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

CSK is a cytoplasmic tyrosine kinase that has been shown to downregulate the tyrosine kinase activity of the c-src oncoprotein through tyrosine phosphorylation of the c-src carboxy terminus (1). Cell transformation by src oncoprotein is caused by several oncogenic mechanisms, which interfere with the carboxy terminal phosphorylation. The CSK could therefore potentially function as an anti-oncogene. CSK is ubiquitously expressed in human tissues as 2 mRNA species of 2.6 and 3.4 kb, although in some tissues and cell lines, only the larger mRNA is detected (2). A yeast 2-hybrid system has been used to identify proteins associated with CSK. The Src homology-3 (SH3) domain of CSK associates with a proline-rich region of PEP, a protein-tyrosine phosphatase expressed in hemopoietic cells (2). This association is highly specific and it is speculated that PEP may be an effector and/or regulator of CSK in T cells and other hemopoietic cells. An in situ hybridization has been used to map the CSK gene to chromosome 15q23-q25 (3).


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