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CRT Inhibitor, iCRT5

A β-catenin-responsive transcription (CRT) inhibitor
Catalog #: 1896
SKU-Size Size Price Qty
1896-5 5 mg
1896-25 25 mg
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Product Details

Alternate Name (Z)-4-(5-(3,4-Dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid
Appearance Yellow solid
Molecular Formula C₁₆H₁₇NO₅S₂
Molecular Weight 367.44
Purity ≥98% by HPLC
Solubility DMSO
PubChem CID
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A potent inhibitor of the β-catenin-responsive transcription (CRT) in the nucleus. iCRT5 inhibits Wnt responsive STF16 luciferase (STF16-Luc) with an IC₅₀ of 18 nM. It acts by disrupting the interaction between β-catenin and TCF4, possibly by direct binding to β-catenin. However, it displays minimal or less prominent effect on non-canonical Wnt signaling and other pathways such as Hh, JAK/STAT, and Notch signaling.

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