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Crizotinib

A potent c-Met and ALK inhibitor
Catalog #: 1934

In stock

SKU-Size Size Price Qty
1934-5 5 mg
$130.00
1934-25 25 mg
$505.00
More Sizes Get Quote

Product Details

Alternate Name 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
Appearance Off-white solid
CAS # 877399-52-5
Molecular Formula C₂₁H₂₂Cl₂FN₅O
Molecular Weight 450.34
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
InChi InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
InChi Key KTEIFNKAUNYNJU-GFCCVEGCSA-N
PubChem CID 11626560
MDL Number MFCD12407409
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A specific, ATP-competitive, small-molecule inhibitor of the receptor tyrosine kinases (RTKs) c-Met and anaplastic lymphoma kinase (ALK). Iinhibits tyrosine phosphorylation of activated ALK at nanomolar concentrations. Inhibits the growth and survival of cell lines dependent upon c-Met or ALK enzymatic activity.


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