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CRIM1 Antibody (CT)

Catalog #: 5287
$325.00

Product Details

Cat # +Size 5287-100
Size 100 µg
Antibody Target CRIM1
Alternate Name Cysteine rich transmembrane BMP regulator 1 (chordin-like), CRIM-1, Cysteine-rich motor neuron 1 protein, Cysteine-rich repeat-containing protein S52
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG1
Immunogen CRIM1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human Crim1.
Accession # Q9NZV1
Gene ID 51232
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation 100 µg (1 mg/ml) in 1X PBS containing 0.02 % sodium azide.
Purification Affinity chromatography purified via peptide column
Species Reactivity Human
Application Western blot, ELISA
Positive Control Western Blot: Jurkat cell lysate
Application & Usage Western Blot: 1 - 2 μg/ml, ELISA. However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CRIM1 (cysteine-rich motor neuron 1), a glycosylated type I transmembrane protein, plays a role in tissue development i.e. capillary formation and maintenance during angiogenesis. It contains an N-terminal IGF-binding protein-like motif and six von Willebrand-like cysteine-rich repeats (CRRs) in its extracellular domain. CRIM1 interacts with BMP4 and BMP7 via the CRRs and functions as an antagonist. CRIM1 is developmentally expressed in a number of tissues including the pancreas, kidney, placenta, brain and blood vessels. CRIM1 may participate in CNS and placental development by interacting with growth factors involved in motor neuron differentiation and survival.


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