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Creatine Kinase MT, Human Recombinant

Plays a central role in energy transduction
Catalog #: P1578
SKU-Size Size Price Qty
P1578-20 20 μg
$105.00
P1578-100 100 μg
$455.00
More Sizes Get Quote

Product Details

Alternate Name Creatine kinase U-type, mitochondrial, Acidic-type mitochondrial creatine kinase, Mia-CK, Ubiquitous mitochondrial creatine kinase, U-MtCK, CKMT1A, CKMT
Gene Symbol CKMT1A, CKMT1B
Gene ID 1159
Accession # P12532
Source E. coli
Appearance Liquid
Physical Form Description In 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl, 10% glycerol
Molecular Weight 45 kDa (403aa) (N-terminus His-Tag)
Purity by SDS-PAGE >95%
Amino Acid Sequence aa 40-417
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Recombinant human CKMT1A protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.


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