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CPTH2 (hydrochloride)

An inhibitor of Histone Acetyltransferase activity of Gcn5
Catalog #: B2815
SKU-Size Size Price Qty
B2815-1 1 mg
B2815-5 5 mg
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Product Details

Alternate Name 4-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole hydrochloride, Histone Acetyltransferase Inhibitor IV, CPTH2
Appearance Crystalline solid
CAS # 2108899-91-6
Molecular Formula C₁₄H₁₅Cl₂N₃S
Molecular Weight 328.26
Purity ≥95%
Solubility 5 mg/ml in ethanol and DMF
16 mg/ml in DMSO
InChi InChI=1S/C14H14ClN3S.ClH/c15-11-7-5-10(6-8-11)13-9-19-14(16-13)18-17-12-3-1-2-4-12;/h5-9H,1-4H2,(H,16,18);1H
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


CPTH2 (hydrochloride) is an inhibitor of Histone Acetyltransferase (HAT) activity of Gcn5. Gcn5 acetylates histones H2B and H3. CPTH2 inhibited HAT reaction in vitro and it decreased acetylation of histone H3 at the specific H3-K14 site at micromolar concentrations. CPTH2 inhibited the Gcn5p dependent network. CPTH2 reduced the growth of adenovirus by inhibiting the lysine acetyltransferase activity of Gcn5.

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