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An EZH2 inhibitor
Catalog #: B2509
SKU-Size Size Price Qty
B2509-1 1 mg
B2509-5 5 mg
More Sizes Get Quote

Product Details

Alternate Name N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]ethyl]indole-3-carboxamide; CPI1205
Appearance Crystalline solid
CAS # 1621862-70-1
Molecular Formula C₂₇H₃₃F₃N₄O₃
Molecular Weight 518.57
Purity ≥98% by HPLC
Solubility >100 mg/ml in DMSO
InChi InChI=1S/C27H33F3N4O3/c1-16-13-23(37-4)21(25(35)32-16)14-31-26(36)24-18(3)34(22-8-6-5-7-20(22)24)17(2)19-9-11-33(12-10-19)15-27(28,29)30/h5-8,13,17,19H,9-12,14-15H2,1-4H3,(H,31,36)(H,32,35)/t17-/m1/s1
PubChem CID 78320408
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


CPI-1205 is a highly potent (biochemical IC₅₀ = 0.002 μM, cellular EC50 = 0.032 μM) and selective inhibitor of the histone lysine methyltransferase EZH2 (biochemical IC₅₀ = 0.002 μM, cellular EC₅₀ = 0.032 μM). Upon oral administration, CPI-1205 selectively inhibits the activity of both wild-type and mutated forms of EZH2.

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