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CPI-455 hydrochloride

A potent and selective inhibitor of KDM5 demethylases
Catalog #: B3254
SKU-Size Size Price Qty
B3254-5 5 mg
$155.00
B3254-25 25 mg
$595.00
More Sizes Get Quote

Product Details

Alternate Name CPI455 HCl; 7-oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile;hydrochloride
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 2095432-28-1
Molecular Formula C₁₆H₁₅ClN₄O
Molecular Weight 314.77
Purity ≥98% by HPLC
Solubility >50 mg/ml DMSO
SMILES CC(C)C1=C(N=C2C(=CNN2C1=O)C#N)C3=CC=CC=C3.Cl
InChi InChI=1S/C16H14N4O.ClH/c1-10(2)13-14(11-6-4-3-5-7-11)19-15-12(8-17)9-18-20(15)16(13)21;/h3-7,9-10,18H,1-2H3;1H
InChi Key SNODPNXOTKXHHH-UHFFFAOYSA-N
PubChem CID 129896721
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CPI-455 hydrochloride is a potent and selective inhibitor of KDM5 demethylases. which reduces survival of drug-tolerant cancer cells. CPI-455 binds to the demethylase active site and selectively inhibits KDM5A-D (IC50s = 2-10 nM) over KDM2-4, 6, and 7 family members (IC50s = 1 to >25 μM). It increases histone H3K4me2/3 methylation in vitro and decreases the number of drug-tolerant cells in PC9 non-small cell lung, M14 melanoma, and SKBR3 breast cancer cell populations.


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