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CPI-444

A potent adenosine A2A receptor antagonist.
Catalog #: B1970
SKU-Size Size Price Qty
B1970-5 5 mg
$135.00
B1970-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name (S)-7-(5-methylfuran-2-yl)-3-((6-(((tetrahydrofuran-3-yl)oxy)methyl)pyridin-2-yl)methyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine; V81444
Appearance Crystalline solid
CAS # 1202402-40-1
Molecular Formula C₂₀H₂₁N₇O₃
Molecular Weight 407.43
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC1=CC=C(O1)C2=C3C(=NC(=N2)N)N(N=N3)CC4=NC(=CC=C4)COC5CCOC5
InChi InChI=1S/C20H21N7O3/c1-12-5-6-16(30-12)17-18-19(24-20(21)23-17)27(26-25-18)9-13-3-2-4-14(22-13)10-29-15-7-8-28-11-15/h2-6,15H,7-11H2,1H3,(H2,21,23,24)/t15-/m0/s1
InChi Key KURQKNMKCGYWRJ-HNNXBMFYSA-N
PubChem CID 44537963
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CPI-444 is a potent adenosine A2A receptor antagonist. Upon oral administration, CPI-444 binds to adenosine A2A receptors expressed on the surface of immune cells, including T-lymphocytes, natural killer (NK) cells, macrophages and dendritic cells (DCs). This prevents tumor-released adenosine from interacting with the A2A receptors on these key immune surveillance cells, thereby abrogating adenosine-induced immunosuppression in the tumor microenvironment.


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