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Cox-2 Antibody

Catalog #: 3362R

In stock

SKU-Size Size Price Qty
3362R-30T 30 µg
$89.00
3362R-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Antibody Target Cox-2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide mapping to the C-terminus of human Cox-2
Accession # P35354
Gene ID 5743
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human
Application Western blot
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 66 kDa human Cox-2. It does not cross-react with Cox-1. Jurkat cell lysate (Cat.# 2401-100) can be used as a positive control.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Nonsteroidal anti-inflammatory drμgs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions throμghout the body, whereas PGs formed by COX-2 primarily mediate pain, fever, and inflammation. COX-1 is constitutively expressed, with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis.


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Li, Weiying et al. (2016) Cyclooxygenase-2 is associated with malignant phenotypes in human lung cancer, Oncol Lett. 2016 Nov;12(5):3836-3844.
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