Product Details
| Antibody Target | Cox-1 |
|---|---|
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Synthetic peptide corresponding to residues surrounding amino acids 586 of mouse Cox-1 |
| Accession # | P22437 |
| Gene ID | 19224 |
| Appearance | Colorless liquid |
| Concentration | 0.2 mg/ml |
| Formulation | 100 µg (0.2 mg/ml) immunoaffinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% sodium azide. |
| Purification | Affinity purified |
| Species Reactivity | Human, mouse, rat |
| Application | Western blot, Immunoprecipitation, Immunohistochemistry |
| Positive Control | IHC: Brain, Cortex |
| Application & Usage | Western blotting (1-4 µg/ml), immunoprecipitation, and Immunohistochemistry(5µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 70 kDa COX-1 of human, mouse and rat origins. It does not cross-react with |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Nonsteroidal anti-inflammatory drμgs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions throμghout the body, whereas PGs formed by COX-2 primarily mediate pain, fever, and inflammation. COX-1 is constitutively expressed, with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis.
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Ghosh S et al (2007) Am. J. Physiol Heart Circ. Physiol. 293: H2910-H2927.
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