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Coumestrol

A biologically active phytoestrogen
Catalog #: B3273
SKU-Size Size Price Qty
B3273-5 5 mg
$95.00
B3273-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name 3,9-dihydroxy-6H-benzofuro[3,2-c][1]benzopyran-6-one NSC-22842
Appearance White to off-white solid
CAS # 479-13-0
Molecular Formula C₁₅H₈O₅
Molecular Weight 268.22
Purity ≥98%
Solubility ~25 mg/ml DMSO
SMILES O=C1OC2=C(C=CC(O)=C2)C3=C1C4=CC=C(O)C=C4O3
InChi InChI=1S/C15H8O5/c16-7-1-3-9-11(5-7)19-14-10-4-2-8(17)6-12(10)20-15(18)13(9)14/h1-6,16-17H
InChi Key ZZIALNLLNHEQPJ-UHFFFAOYSA-N
PubChem CID 5281707
MDL Number MFCD00016885
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Coumestrol is naturally occurring phytoestrogen. It competitively binds the estrogen receptors ERα (IC50 = 11 nM) and ERβ (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells. Coumestrol also acts as a weak antagonist of pregnane X receptor (IC50 = 12 μM) as well as a potential inverse agonist of the constitutive androstane receptor (EC50 = 30 μM).


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