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Core Histones (Hela)

Mixture of human core histones involved in gene transcription
Catalog #: 7677
SKU-Size Size Price Qty
7677-50 50 μg
7677-100 100 μg
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Product Details

Alternate Name HeLa Core Histones, Core Histone Octamer
Source Highly purified mixture of human core histones (H2A, H2B, H3, and H4) purified from HeLa cells. Histones are separated from DNA under high salt conditions.
Appearance Liquid
Physical Form Description An aqueous solution in 50 mM sodium phosphate buffer, pH 6.8 and 2.5 M NaCl
Purity by SDS-PAGE ≥95%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans


A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around a histone octamer consisting of two copies of each of the core histones, H2A, H2B, H3, and H4. The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core.2 Histone H3 undergoes many modifications which include acetylation, methylation, and phosphorylation that are important for regulation of gene transcription.

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