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Product Details
| Alternate Name | D,L-1,2-Anhydro-myo-inositol; CBE |
|---|---|
| Appearance | White to off-white solid |
| CAS # | 6090-95-5 |
| Molecular Formula | C₆H₁₀O₅ |
| Molecular Weight | 162.14 |
| Purity | ≥98% |
| Solubility | DMSO ~25 mg/ml) |
| SMILES | C1(C(C(C2C(C1O)O2)O)O)O |
| InChi | InChI=1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H/t1-,2-,3+,4+,5-,6+/m0/s1 |
| InChi Key | ZHMWOVGZCINIHW-FTYOSCRSSA-N |
| PubChem CID | 119054 |
| MDL Number | MFCD00077326 |
| Handling | Protect from air and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Conduritol B epoxide (CBE) is an irreversible inhibitor of glucocerebrosidase, also known as acid β-glucosidase, glucosylceramidase, GBA, or GBA1 (IC₅₀ = 9 μM). Inhibition of this lysosomal glucosidase results in the accumulation of glucocerebroside without affecting cell viability, lysosomal enzyme release, or the activity of intracellular enzymes. It also does not inhibit non-lysosomal glucosylceramidase or cytosolic β-glucosidase.
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