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Conduritol B Epoxide

An irreversible inhibitor of glucocerebrosidase
Catalog #: 9574
SKU-Size Size Price Qty
9574-5 5 mg
$115.00
9574-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name D,L-1,2-Anhydro-myo-inositol; CBE
Appearance White to off-white solid
CAS # 6090-95-5
Molecular Formula C₆H₁₀O₅
Molecular Weight 162.14
Purity ≥98%
Solubility DMSO ~25 mg/ml)
SMILES C1(C(C(C2C(C1O)O2)O)O)O
InChi InChI=1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H/t1-,2-,3+,4+,5-,6+/m0/s1
InChi Key ZHMWOVGZCINIHW-FTYOSCRSSA-N
PubChem CID 119054
MDL Number MFCD00077326
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Conduritol B epoxide (CBE) is an irreversible inhibitor of glucocerebrosidase, also known as acid β-glucosidase, glucosylceramidase, GBA, or GBA1 (IC₅₀ = 9 μM). Inhibition of this lysosomal glucosidase results in the accumulation of glucocerebroside without affecting cell viability, lysosomal enzyme release, or the activity of intracellular enzymes. It also does not inhibit non-lysosomal glucosylceramidase or cytosolic β-glucosidase.


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