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Compound E

A potent, selective inhibitor of γ-secretase
Catalog #: 1949
SKU-Size Size Price Qty
1949-250 250 µg
$95.00
1949-1000 1 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name (2S)-2-([(3,5-Difluorophenyl)acetyl]amino)-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide
Appearance White to off-white solid
CAS # 209986-17-4
Molecular Formula C₂₇H₂₄F₂N₄O₃
Molecular Weight 490.5
Purity ≥98% by HPLC
Solubility DMSO (~ 10 mg/ml)
SMILES CC(C(=O)NC1C(=O)N(C2=CC=CC=C2C(=N1)C3=CC=CC=C3)C)NC(=O)CC4=CC(=CC(=C4)F)F
InChi InChI=1S/C27H24F2N4O3/c1-16(30-23(34)14-17-12-19(28)15-20(29)13-17)26(35)32-25-27(36)33(2)22-11-7-6-10-21(22)24(31-25)18-8-4-3-5-9-18/h3-13,15-16,25H,14H2,1-2H3,(H,30,34)(H,32,35)/t16-,25+/m0/s1
InChi Key JNGZXGGOCLZBFB-IVCQMTBJSA-N
PubChem CID 11306390
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A potent, selective, non-transition state and non-competitive inhibitor of γ-secretase (IC₅₀ = 0.3 nM for total β-amyloid) and Notch processing. At higher concentrations (20-400 µM), only weakly affects the presenilase activity.


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