Compound 401

A DNA-PK inhibitor
Catalog #: 1657 | abID:

Product Details

Cat # +Size 1657-5
Size 5 mg
Alternate Name 2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one
Appearance White to off-white solid
CAS # 168425-64-7
Molecular Formula C₁₆H₁₅N₃O₂
Molecular Weight 281.31
Purity ≥97% by HPLC
Solubility DMSO (10 mM) or EtOH (5 mM)
InChi InChI=1S/C16H15N3O2/c20-15-11-14(18-7-9-21-10-8-18)17-16-13-4-2-1-3-12(13)5-6-19(15)16/h1-6,11H,7-10H2
PubChem CID 10039361
MDL Number MFCD10568147
Handling Protect from air and light
Storage Conditions 4°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) (IC₅₀ = 0.28 µM) that also targets mTOR (IC₅₀ = 5. 3µM), but not PI 3-K in vitro. Induces apoptosis in vitro.

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