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Complement C5, Human Plasma

A potent chemotactic factor for human peripheral blood neutrophils and monocytes
Catalog #: P1273
SKU-Size Size Price Qty
P1273-25 25 μg
$125.00
P1273-100 100 μg
$450.00
More Sizes Get Quote

Product Details

Alternate Name C5, CPAMD4
Gene Symbol C5
Gene ID 727
Accession # P01031
Source Human Plasma
Appearance Liquid
Physical Form Description In PBS, pH 7.4
Molecular Weight 190 kDa
Purity by SDS-PAGE ≥95%
Handling Thaw on ice, and aliquot into smaller working quantities to avoid multiple freeze/thaw cycles.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

Complement Component 5 (C5) plays a central role in inflammatory and cellular death processes. This protein is composed of alpha and beta polypeptide chains that are linked by a disulfide bridge. The protein gets cleaved into C5a and C5b which are subsequently responsible for chemotaxis, inflammation, and initiating the formation of the membrane attack complex (MAC). Drugs that inhibit complement C5 have been used in Paroxysmal nocturnal hemoglobinuria (PNH) patients to lessen thrombotic complications by lessening intravascular hemolysis.


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