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Combretastatin A4

A vascular disrupting, antineoplastic and microtubule-depolymerizing agent.
Catalog #: 2239
SKU-Size Size Price Qty
2239-10 10 mg
$115.00
2239-50 50 mg
$475.00
More Sizes Get Quote

Product Details

Alternate Name 2-Methoxy-5-[(1Z)-2-(3,4,5-trimetho-xyphenyl)ethenyl]phenol; CRC 87-09, NSC 817373
Appearance White to off-white solid
CAS # 117048-59-6
Molecular Formula C₁₈H₂₀O₅
Molecular Weight 316.35
Purity ≥98% by HPLC
Solubility DMSO (100 mM) or EtOH (100 mM)
SMILES COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)O
InChi InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-
InChi Key HVXBOLULGPECHP-WAYWQWQTSA-N
PubChem CID 5351344
MDL Number MFCD03453309
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A vascular disrupting, antineoplastic and microtubule-depolymerizing agent. Binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, it disrupts the engagement of the endothelial cell–specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and thus the activity of the VE-cadherin/β-catenin/Akt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation.


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