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CNTF, rat recombinant

A potent neural factor promoting survivability and differentiation of neuronal cell types.
Catalog #: 4019
SKU-Size Size Price Qty
4019-20 20 μg
4019-100 100 μg
4019-1000 1 mg
More Sizes Get Quote

Product Details

Alternate Name HCNTF, CNTF, Ciliary Neurotrophic Factor.
Gene Symbol CNTF
Gene ID 1270
Accession # P26441
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized from 0.025 % NaHCO₃
Molecular Weight 22.834 kDa
Purity by SDS-PAGE ≥99%
Biological Activity Fully biologically active by its ability to phosphorylate STAT3 in several cells lines.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile ddH₂O or 0.4 % NaHCO₃ adjusted to pH 8-9 to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffer, preferably in the presence of carrier protein.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


CNTF is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. CNTF is a survival factor for various neuronal cell types and seems to prevent the degeneration of motor axons after axotomy. CNTF Recombinant Rat produced in E.Coli is a single, non-glycosylated polypeptide chain containing 200 amino acids and having a molecular mass of 22834 Dalton. The CNTF is purified by proprietary chromatographic techniques.

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