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CNTF, rat recombinant

A potent neural factor promoting survivability and differentiation of neuronal cell types.
Catalog #: 4019
SKU-Size Size Price Qty
4019-20 20 μg
$195.00
4019-100 100 μg
$565.00
4019-1000 1 mg
$3,000.00
More Sizes Get Quote

Product Details

Alternate Name HCNTF, CNTF, Ciliary Neurotrophic Factor.
Gene Symbol CNTF
Gene ID 1270
Accession # P26441
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized from 0.025 % NaHCO₃
Molecular Weight 22.834 kDa
Purity by SDS-PAGE ≥99%
Biological Activity Fully biologically active by its ability to phosphorylate STAT3 in several cells lines.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile ddH₂O or 0.4 % NaHCO₃ adjusted to pH 8-9 to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffer, preferably in the presence of carrier protein.
Amino Acid Sequence AFAEQTPLTLHRRDL SSRSIWLARKIRSDLTALME SYVKHQGLNKNINLD SVDGVPVASTDRWS EMTEAERLQENLQA YRTFQGMLTKLLEDQRV HFTPTEGDFHQAI HTLMLQVSAFAYQLE ELMVLLEQKIPENEA DGMPATVGDGGLFE KKLWGLKVLQELSQW TVRSIHDLRVISSHQMGIS ALESHYGAKDKQM
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

CNTF is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. CNTF is a survival factor for various neuronal cell types and seems to prevent the degeneration of motor axons after axotomy. CNTF Recombinant Rat produced in E.Coli is a single, non-glycosylated polypeptide chain containing 200 amino acids and having a molecular mass of 22834 Dalton. The CNTF is purified by proprietary chromatographic techniques.


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