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An inhibitor of p38α-mediated MK2a phosphorylation
Catalog #: B2991
SKU-Size Size Price Qty
B2991-1 1 mg
B2991-5 5 mg
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Product Details

Alternate Name 4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide; 2'-fluoro-N-(4-hydroxyphenyl)-[1,1'-biphenyl]-4-butanamide; Mitogen-activated protein kinase-activated protein kinase 2a Inhibitor; MK2a Inhibitor
Appearance Pale pink solid
CAS # 41179-33-3
Molecular Formula C₂₂H₂₀FN₀O₂
Molecular Weight 349.4
Purity ≥99%
Solubility ~35 mg/ml in DMSO and Ethanol
InChi InChI=1S/C22H20FNO2/c23-21-6-2-1-5-20(21)17-10-8-16(9-11-17)4-3-7-22(26)24-18-12-14-19(25)15-13-18/h1-2,5-6,8-15,25H,3-4,7H2,(H,24,26)
PubChem CID 11382492
MDL Number MFCD08703098
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


MK2a inhibitor is a substrate-selective inhibitor of p38α MAPK that selectively inhibits p38α-dependent phosphorylation of mitogen-activated protein kinase-activated protein kinase 2 (MK2a) with a K(i)(app) of 330 nM. It does not inhibit the phosphorylation of ATF-2 and MBP. It inhibits proliferation of U87, A172, and U251 glioblastoma cells with EC₅₀ values of 0.6-1 μM by inhibition of tubulin polymerization and induction of apoptosis.

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