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Product Details
| Alternate Name | 10-carboxymethyl-9-acridanone, Cridanimod, 9-Oxo-10(9H)-acridineacetic acid |
|---|---|
| Appearance | Yellow solid |
| CAS # | 38609-97-1 |
| Molecular Formula | C₁₅H₁₁NO₃ |
| Molecular Weight | 253.25 |
| Purity | ≥98% by HPLC |
| Solubility | >25 mg/ml in DMSO |
| SMILES | C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3N2CC(=O)O |
| InChi | InChI=1S/C15H11NO3/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16/h1-8H,9H2,(H,17,18) |
| InChi Key | UOMKBIIXHQIERR-UHFFFAOYSA-N |
| PubChem CID | 38072 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
CMA is a murine-selective STING agonist (Kd = 3.5 μM). It directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route. CMA triggers type I IFN response in murine macrophages. However, does not activate human STING signaling.
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