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CMA

A murine-selective STING agonist
Catalog #: B2397

In stock

SKU-Size Size Price Qty
B2397-5 5 mg
$85.00
B2397-25 25 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 10-carboxymethyl-9-acridanone, Cridanimod, 9-Oxo-10(9H)-acridineacetic acid
Appearance Yellow solid
CAS # 38609-97-1
Molecular Formula C₁₅H₁₁NO₃
Molecular Weight 253.25
Purity ≥98% by HPLC
Solubility >25 mg/ml in DMSO
SMILES C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3N2CC(=O)O
InChi InChI=1S/C15H11NO3/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16/h1-8H,9H2,(H,17,18)
InChi Key UOMKBIIXHQIERR-UHFFFAOYSA-N
PubChem CID 38072
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CMA is a murine-selective STING agonist (Kd = 3.5 μM). It directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route. CMA triggers type I IFN response in murine macrophages. However, does not activate human STING signaling.


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