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CM-272

A dual G9a/DNA methyltransferases (DNMTs) inhibitor
Catalog #: B3250
SKU-Size Size Price Qty
B3250-5 5 mg
$165.00
B3250-25 25 mg
$650.00
More Sizes Get Quote

Product Details

Alternate Name [6-Methoxy-2-(5-methyl-furan-2-yl)-7-(3-pyrrolidin-1-yl-propoxy)-quinolin-4-yl]-(1-methyl-piperidin-4-yl)-amine; CM272
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 1846570-31-7
Molecular Formula C₂₈H₃₈N₄O₃
Molecular Weight 478.64
Purity ≥98% by HPLC
Solubility >50 mg/ml DMSO
SMILES CN1CCC(NC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C24)CC1
InChi InChI=1S/C28H38N4O3/c1-20-7-8-26(35-20)25-18-23(29-21-9-14-31(2)15-10-21)22-17-27(33-3)28(19-24(22)30-25)34-16-6-13-32-11-4-5-12-32/h7-8,17-19,21H,4-6,9-16H2,1-3H3,(H,29,30)
InChi Key RLQLKZTYUYIWDB-UHFFFAOYSA-N
PubChem CID 118607432
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CM-272 is a potent, selective, substrate-competitive and reversible dual G9a/DNA methyltransferases (DNMTs) inhibitor. CM-272 inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP with IC50s of 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively. CM-272 inhibits cell proliferation and promotes apoptosis, inducing IFN-stimulated genes and immunogenic cell death. Displays anti-tumor activity.


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