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Cloxacillin sodium

A β-lactam antibiotic
Catalog #: B2687
SKU-Size Size Price Qty
B2687-50 50 mg
B2687-250 250 mg
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Product Details

Alternate Name (2S,5R,6R)-6-[[[3-(2-chlorophenyl)-5-methyl-4-isoxazolyl]carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, monosodium salt, Sodium cloxacillin
Peptide Sequence N/A
Appearance White to off-white solid
CAS # 642-78-4
Molecular Formula C19H17ClN3O5S • Na
Molecular Weight 457.9
Purity ≥95%
Solubility ~15 mg/ml DMSO
SMILES CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].[Na+]
InChi InChI=1S/C19H18ClN3O5S.Na/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);/q;+1/p-1/t13-,14+,17-;/m1./s1
PubChem CID 23675320
MDL Number MFCD00063568
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cloxacillin sodium is a β-lactam antibiotic of penicillin subclass, which inhibits bacterial cell wall synthesis by targeting the proteoglycan synthesis. Cloxacillin has a narrow spectrum of action and is effective against Gram-positive organisms. Cloxacillin binds to S. aureus penicillin-binding protein 1 (PBP1), PBP2, PBP3, and PBP4 (IC50s = 0.04, 0.12, 0.21, and 2.5 µg/ml, respectively). Cloxacillin is resistant to the action of β-lactamase and therefore preferentially used for treatment of Staphylococcal infections.

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