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Anti-Cleaved-Caspase-1 Antibody

Polyclonal Antibody to detect active form of Casepase-1 in Human
Catalog #: A1004
$265.00

Product Details

Cat # +Size A1004-50
Size 50 µl
Antibody Target Cleaved Caspase-1
Alternate Name CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45, IL1BC, IL1BCE, CASP1
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthesized peptide derived from human Caspase-1 between Ser 129 - Asn 205
Accession # P29466
Gene ID 834
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation 50 µl purified antibody supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Purification Affinity purified rabbit IgG
Species Reactivity Human
Application Western Blot, Immunohistochemistry, ELISA,
Positive Control Western blot
Application & Usage WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Cleaved-caspase-1 (D210) detects levels of fragment of activated Caspase-1 protein resulting from cleavage adjacent to D210.


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