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Citrullinated Histone H1.4 (R53) Antibody

A critical mediator of higher-order chromatin structure
Catalog #: A2317
SKU-Size Size Price Qty
A2317-50 50 µl
$165.00
A2317-100 100 µl
$285.00
More Sizes Get Quote

Product Details

Antibody Target Human Histone H1.4 citrullinated at R53
Alternate Name H1.4 Linker Histone, Cluster Member; Histone Cluster 1 H1 Family Member E; H1 Histone Family, Member 4; Histone Cluster 1, H1e; Histone 1, H1e; Histone H1s-4; Histone H1.4; Histone H1b; HIST1H1E; H1s-4; H1.4; H1F4; DJ221C16.5; RMNS; H1-4; H1E; H1e
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide of human histone H1.4 citrullinated at R53
Accession # P10412
Gene ID 3008
Appearance Liquid
Formulation TBS, pH 7.4, with 50% glycerol, 0.1% BSA, 0.02% sodium azide
Purification Peptide affinity purification
Species Reactivity Human
Application Western Blotting
Handling The antibody solution should be gently mixed before use
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Histone H1.4 is a nuclear protein that binds to linker DNA between nucleosomes to form chromatin fibers. Histone H1.4 is expressed in most somatic cell types, and is necessary for the ordering of nucleosomes into higher-order structures and the compaction of chromatin into its condensed form. The arginine at position 53 can be citrullinated by protein-arginine deiminase 4 (PAD4), which releases Histone H1.4 from the histone complex, leading to chromatin decondensation. Aberrations in Histone H1.4 has been linked to intellectual disability disorders such as Rahman Syndrome.


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