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CITED2 Antibody (NT)

Catalog #: 5286
$325.00

Product Details

Cat # +Size 5286-100
Size 100 µg
Antibody Target CITED2
Alternate Name Cbp/p300-interacting transactivator 2, melanocyte-specific gene 1-related gene 1, MSG-related protein 1, MRG1, melanocyte specific gene 2, MSG2, ER154-like, ASD8, VSD2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG1
Immunogen CITED2 antibody was raised against an 18 amino acid peptide near the amino terminus of human CITED2.
Accession # Q99967
Gene ID 10370
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation 100 µg (1 mg/ml) in 1X PBS containing 0.02 % sodium azide.
Purification Affinity chromatography purified via peptide column
Species Reactivity Human, mouse, rat
Application Western blot, ELISA
Positive Control Western Blot: Jurkat cell lysate
Application & Usage Western Blot: 1 - 2 μg/ml, ELISA. However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CITED2 was initially identified as a potential transcriptional activator with significant homology to MSG1, a melanocyte-specific nuclear protein. CITED2 interacts with the histone acetyltransferase p300/CBP and acts as a coactivator to several DNA-binding transcription factors such as HIF-1 and AP-2. CITED2 also controls proliferation of mouse embryonic fibroblasts via the polycomb group genes Bmi-1 and Mel18 and the tumor suppressor Ink4a/Arf. CITED2 has also been found to be an essential regulator of adult hematopoietic stem cells (HSCs), with conditional deletion of CITED2 in the adult mouse resulting in the loss of HSCs, multilineage bone marrow failure and increased lethality.


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