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A Cdk4/6 inhibitor
Catalog #: B2929
SKU-Size Size Price Qty
B2929-5 5 mg
B2929-25 25 mg
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Product Details

Alternate Name trans-4-[[6-(Ethylamino)-2-[[1-(phenylmethyl)-1H-indol-5-yl]amino]-4-pyrimidinyl]amino]-cyclohexanol; 4-[[2-[(1-benzylindol-5-yl)amino]-6-(ethylamino)pyrimidin-4-yl]amino]cyclohexan-1-ol; Cdk4/6 Inhibitor IV
Appearance A crystalline solid
CAS # 359886-84-3
Molecular Formula C₂₇H₃₂N₆O
Molecular Weight 456.58
Purity 95%
Solubility ~1 mg/ml in in Ethanol, ~30 mg/ml in DMSO and DMF
InChi InChI=1S/C27H32N6O/c1-2-28-25-17-26(29-21-8-11-23(34)12-9-21)32-27(31-25)30-22-10-13-24-20(16-22)14-15-33(24)18-19-6-4-3-5-7-19/h3-7,10,13-17,21,23,34H,2,8-9,11-12,18H2,1H3,(H3,28,29,30,31,32)
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


CINK4 is a triaminopyrimidine derivative that inhibits Cdk4/cyclin D1 and Cdk6/cyclin D1 activity with IC₅₀ values of 1.5 and 5.6 μM, respectively. It reduces retinoblastoma protein phosphorylation at Ser780 and Ser795 and induces cell cycle arrest in the G1 phase in U2OS and MRC-5 cells at 5-10 µM. Administration of CINK4 at 30 mg/kg, i.p. for 29 days, suppresses tumor growth in mice bearing human HCT116 colon carcinoma xenografts.

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