Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

CINK4

A Cdk4/6 inhibitor
Catalog #: B2929
SKU-Size Size Price Qty
B2929-5 5 mg
$145.00
B2929-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name trans-4-[[6-(Ethylamino)-2-[[1-(phenylmethyl)-1H-indol-5-yl]amino]-4-pyrimidinyl]amino]-cyclohexanol; 4-[[2-[(1-benzylindol-5-yl)amino]-6-(ethylamino)pyrimidin-4-yl]amino]cyclohexan-1-ol; Cdk4/6 Inhibitor IV
Appearance A crystalline solid
CAS # 359886-84-3
Molecular Formula C₂₇H₃₂N₆O
Molecular Weight 456.58
Purity 95%
Solubility ~1 mg/ml in in Ethanol, ~30 mg/ml in DMSO and DMF
SMILES CCNC1=CC(=NC(=N1)NC2=CC3=C(C=C2)N(C=C3)CC4=CC=CC=C4)NC5CCC(CC5)O
InChi InChI=1S/C27H32N6O/c1-2-28-25-17-26(29-21-8-11-23(34)12-9-21)32-27(31-25)30-22-10-13-24-20(16-22)14-15-33(24)18-19-6-4-3-5-7-19/h3-7,10,13-17,21,23,34H,2,8-9,11-12,18H2,1H3,(H3,28,29,30,31,32)
InChi Key YVXCDLCJCIDFHE-UHFFFAOYSA-N
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

CINK4 is a triaminopyrimidine derivative that inhibits Cdk4/cyclin D1 and Cdk6/cyclin D1 activity with IC₅₀ values of 1.5 and 5.6 μM, respectively. It reduces retinoblastoma protein phosphorylation at Ser780 and Ser795 and induces cell cycle arrest in the G1 phase in U2OS and MRC-5 cells at 5-10 µM. Administration of CINK4 at 30 mg/kg, i.p. for 29 days, suppresses tumor growth in mice bearing human HCT116 colon carcinoma xenografts.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.