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Cinacalcet hydrochloride

An allosteric agonist of the calcium-sensing receptor
Catalog #: B3297
SKU-Size Size Price Qty
B3297-5 5 mg
$75.00
B3297-25 25 mg
$275.00
More Sizes Get Quote

Product Details

Alternate Name Mimpara AMG 073 αR-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethanamine, monohydrochloride KRN1493
Appearance White solid
CAS # 364782-34-3
Molecular Formula C₂₂H₂₂F₃N.HCl
Molecular Weight 393.87
Purity ≥98% by HPLC
Solubility >35 mg/ml DMSO
SMILES CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl
InChi InChI=1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1
InChi Key QANQWUQOEJZMLL-PKLMIRHRSA-N
PubChem CID 156418
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cinacalcet is a calcimimetic and an allosteric agonist of the calcium-sensing receptor. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels.


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