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Cilomilast

A PDE4 inhibitor
Catalog #: B2182
SKU-Size Size Price Qty
B2182-5 5 mg
$115.00
B2182-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name cis-4-Cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylic acid; SB 207499, SB-207499; Ariflo
Appearance White to off-white solid
CAS # 153259-65-5
Molecular Formula C₂₀H₂₅NO₄
Molecular Weight 343.42
Purity ≥98% by HPLC
Solubility DMSO (~15 mg/ml)
SMILES COC1=C(C=C(C=C1)C2(CCC(CC2)C(=O)O)C#N)OC3CCCC3
InChi InChI=1S/C20H25NO4/c1-24-17-7-6-15(12-18(17)25-16-4-2-3-5-16)20(13-21)10-8-14(9-11-20)19(22)23/h6-7,12,14,16H,2-5,8-11H2,1H3,(H,22,23)
InChi Key CFBUZOUXXHZCFB-UHFFFAOYSA-N
PubChem CID 151170
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cilomilast is an orally active, second-generation phosphodiesterase (PDE) inhibitor that may be effective in the treatment of asthma and chronic obstructive pulmonary disease (COPD). It has high selectivity for the cyclic AMP-specific, or PDE4, isoenzyme that predominates in pro-inflammatory and immune cells and is ten-fold more selective for PDE4D than for PDE4A, B and C.


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