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Cilofexor

A farnesoid X receptor (FXR) agonist
Catalog #: B2604
SKU-Size Size Price Qty
B2604-1 1 mg
$75.00
B2604-5 5 mg
$275.00
More Sizes Get Quote

Product Details

Alternate Name GS-9674, GS9674, GS 9674, 2-(3-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-3-hydroxyazetidin-1-yl)isonicotinic acid
Peptide Sequence N/A
Appearance White to off-white solid
CAS # 1418274-28-8
Molecular Formula C₂₈H₂₂Cl₃N₃O₅
Molecular Weight 586.85
Purity ≥98% by HPLC
Solubility >50 mg/ml in DMSO
SMILES C1CC1C2=C(C(=NO2)C3=C(C=CC=C3Cl)Cl)COC4=CC(=C(C=C4)C5(CN(C5)C6=NC=CC(=C6)C(=O)O)O)Cl
InChi InChI=1S/C28H22Cl3N3O5/c29-20-2-1-3-21(30)24(20)25-18(26(39-33-25)15-4-5-15)12-38-17-6-7-19(22(31)11-17)28 (37)13-34(14-28)23-10-16(27(35)36)8-9-32-23/h1-3,6-11,15,37H,4-5,12-14H2,(H,35,36)
InChi Key KZSKGLFYQAYZCO-UHFFFAOYSA-N
PubChem CID 71228883
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cilofexor (GS-9674), is a nonsteroidal bile acid farnesoid X receptor (FXR) agonist. It improves markers of cholestasis and liver injury in patients with PSC. PSC is an incurable rare chronic liver disease triggered by environmental, immunobiologic and genetic underpinnings resulting in imbalance in bile acids homeostasis that leads to cholestasis with inflammation and fibrosis of the bile ducts.


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