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An integrin αVβ3 receptor antagonist
Catalog #: B2365
SKU-Size Size Price Qty
B2365-5 5 mg
B2365-25 25 mg
More Sizes Get Quote

Product Details

Alternate Name EMD-121974,cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-N-methyl-L-valyl)
Appearance Crystalline solid
CAS # 188968-51-6
Molecular Formula C₂₇H₄₀N₈O₇
Molecular Weight 588.7
Purity ≥98%
Solubility >20 mg/ml (DMSO)
InChi InChI=1S/C27H40N8O7/c1-15(2)22-25(41)33-17(10-7-11-30-27(28)29)23(39)31-14-20(36)32-18(13-21(37)38)24(40)34-19(26(42)35(22)3)12-16-8-5-4-6-9-16/h4-6,8-9,15,17-19,22H,7,10-14H2,1-3H3,(H,31,39)(H,32,36)(H,33,41)(H,34,40)(H,37,38)(H4,28,29,30)/t17-,18-,19+,2
PubChem CID 176873
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cilengitide is a cyclo-(Arg-Gly-Asp-D-Phe-Val) (cRGDfV) peptide that acts as an integrin αVβ3 receptor antagonist. It inhibits adhesion and induces apoptosis of U87MG and U373MG malignant glioma (MG) cells, but not U251MG cells that lack the integrin αVβ3 receptor, in vitro at a concentration of 20 μg/ml.

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