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A dipeptidase (dehydropeptidase I inhibitor
Catalog #: B2689
SKU-Size Size Price Qty
B2689-10 10 mg
B2689-50 50 mg
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Product Details

Alternate Name (2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic acid
Peptide Sequence N/A
Appearance White to off-white solid
CAS # 82009-34-5
Molecular Formula C₁₆H₂₆N₂O₅S
Molecular Weight 358.5
Purity ≥98%
Solubility ~ 10 mg/ml DMSO
SMILES OC([[email protected]@H](N)CSCCCC/C=C(C(O)=O)\NC([[email protected]@H]1C(C)(C)C1)=O)=O
InChi InChI=1S/C16H26N2O5S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23)/b12-6-/t10-,11+/m1/s1
PubChem CID 6435415
MDL Number MFCD00867379
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
USAGE For Research Use Only! Not For Use in Humans.


Cilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase. It inhibits human renal dipeptidase (Ki = 0.7 μM), porcine dipeptidase (IC50 = 0.11 μM), and bacterial metallo-β-lactamase CphA from A. hydrophila (IC50 = 178 μM). Cilastatin (200 μg/ml) protects primary porcine renal proximal tubular epithelial cells from nephrotoxicity and apoptosis induced by vancomycin.

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