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CIL56

A selective ferroptosis inducer
Catalog #: B3248
SKU-Size Size Price Qty
B3248-1 1 mg
$75.00
B3248-5 5 mg
$255.00
More Sizes Get Quote

Product Details

Alternate Name 2,7-bis(1-piperidinylsulfonyl)-9H-fluoren-9-one, oxime
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 300802-28-2
Molecular Formula C₂₃H₂₇N₃O₅S₂
Molecular Weight 489.60
Purity ≥98% by HPLC
Solubility ~10 mg/ml DMSO
SMILES C1CCN(CC1)S(=O)(=O)C2=CC3=C(C=C2)C4=C(C3=NO)C=C(C=C4)S(=O)(=O)N5CCCCC5
InChi InChI=1S/C23H27N3O5S2/c27-24-23-21-15-17(32(28,29)25-11-3-1-4-12-25)7-9-19(21)20-10-8-18(16-22(20)23)33(30,31)26-13-5-2-6-14-26/h7-10,15-16,27H,1-6,11-14H2
InChi Key XYZXEEIUKQGUHB-UHFFFAOYSA-N
PubChem CID 654092
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CIL56 is a small molecule that acts as a selective ferroptosis inducer through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated, monounsaturated, and polyunsaturated fatty acids in HT-1080 cells in vitro. HT-1080 cells lacking acetyl-CoA carboxylase 1 (ACC1), the rate-limiting enzyme in fatty acid synthesis, exhibit 5-fold resistance to CIL56 treatment, indicating ACC1 activity sensitizes cells to CIL56-induced cell death.


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