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CID-5721353

A potent B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor)
Catalog #: B1275
SKU-Size Size Price Qty
B1275-5 5 mg
$165.00
B1275-25 25 mg
$650.00
More Sizes Get Quote

Product Details

Alternate Name 2-((5Z)-5-(5-Bromo-2-oxo-1H-indol-3-ylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanedioic acid
Appearance Red solid
CAS # 301356-95-6 
Molecular Formula C₁₅H₉BrN₂O₆S₂
Molecular Weight 457.23
Purity ≥98% by HPLC
Solubility DMSO
SMILES C1=CC2=C(C=C1Br)C(=C3C(=O)N(C(=S)S3)C(CC(=O)O)C(=O)O)C(=O)N2
InChi InChI=1S/C15H9BrN2O6S2/c16-5-1-2-7-6(3-5)10(12(21)17-7)11-13(22)18(15(25)26-11)8(14(23)24)4-9(19)20/h1-3,8H,4H2,(H,17,21)(H,19,20)(H,23,24)/b11-10-
InChi Key QGNRETMYLHRUBB-KHPPLWFESA-N
PubChem CID 5721353
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CID-5721353 is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor). disrupted BCL6/corepressor complexes in vitro and in vivo, and was shown to bind the critical site within the BTB groove. This compound could induce expression of BCL6 target genes and kill BCL6-positive DLBCL cell lines. In xenotransplantation experiments, the compound was non-toxic and potently suppressed DLBCL tumors in vivo.


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