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cIAP-1/HIAP-2 Antibody

Catalog #: 3180
SKU-Size Size Price Qty
3180-30T 30 µg
$89.00
3180-100 100 µg
$280.00
More Sizes Get Quote

Product Details

Antibody Target cIAP-1/HIAP-2
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 530 of human cIAP-1
Accession # Q13490
Gene ID 329
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 0.5 mg/ml in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blot, Immunohistochemistry
Positive Control Western Blot: Jurkat cell lysate. IHC: Kidney tissue
Application & Usage Western blot analysis (0.5-4 µg/ml), and Immunohistochemistry (5 µg/ml). However, the optimal conditions should be determined individually. Jurkat cell lysate and rat kidney tissue lysate can be used as positive controls.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Apoptosis can be inhibited by a group of proteins called inhibitors of apoptosis (IAPs). These proteins contain a BIR (baculovirus IAP repeat) domain near the amino-terminus. The BIR domain can bind some caspases. Many members of the IAP family of proteins block proteolytic activation of caspase-3 and –7. For example, XIAP, cIAP-1 and cIAP-2 appear to block cytochrome c-induced activation of caspase-9, thereby preventing initiation of the caspase cascade. Since cIAP-1 and cIAP-2 were first identified as components in the cytosolic death domain-induced complex associated with the TNF family of receptors, they may inhibit apoptosis by additional mechanisms.


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