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A type II JAK2 inhibitor
Catalog #: B2475
SKU-Size Size Price Qty
B2475-5 5 mg
B2475-25 25 mg
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Product Details

Alternate Name CHZ-868; N-(4-((2-((2,4-difluorophenyl)amino)-1,4-dimethyl-1H-benzo[d]imidazol-5-yl)oxy)pyridin-2-yl)acetamide
Appearance Crystalline solid
CAS # 1895895-38-1
Molecular Formula C₂₂H₁₉F₂N₅O₂
Molecular Weight 423.42
Purity ≥98% by HPLC
Solubility >100 mg/ml DMSO
InChi InChI=1S/C22H19F2N5O2/c1-12-19(31-15-8-9-25-20(11-15)26-13(2)30)7-6-18-21(12)28-22(29(18)3)27-17-5-4-14(23) 10-16(17)24/h4-11H,1-3H3,(H,27,28)(H,25,26,30)
PubChem CID 91885989
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions 20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


CHZ868 is a potent and selective type II JAK2 inhibitor (IC₅₀ = 110 nM). JAK2 and MPL mutant cell lines are sensitive to CHZ868, including type I JAK inhibitor persistent cells. CHZ868 displays significant activity in murine MPN models and induces reductions in mutant allele burden not observed with type I JAK inhibitors.

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