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Cholesteryl Hemisuccinate

A detergent that stabilizes GPCRs
Catalog #: B1978
SKU-Size Size Price Qty
B1978-1G 1 g
B1978-5G 5 g
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Product Details

Alternate Name 3β-Hydroxy-5-cholestene 3-hemisuccinate; 5-Cholesten-3β-ol 3-hemisuccinate; CHS
Appearance White to off-white solid
CAS # 1510-21-0
Molecular Formula C₃₁H₅₀O₄
Molecular Weight 486.73
Purity ≥95%
Solubility EtOH (warm; with faint turbidity)
InChi InChI=1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1
PubChem CID 65082
MDL Number MFCD00037705
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cholesteryl hemisuccinate is a useful cholesterol-based detergent that increases the stability of G protein-coupled receptors (GPCRs). Together with mutagenesis studies and recent GPCR structures, it has been determined that stabilization is attained through a combination of specific sterol binding to GPCRs and modulation of micelle morphology.

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