Product Details
| Alternate Name | N⁴-(7-Chloro-4-quinolinyl)-N¹,N¹-dimethyl-1,4-pentanediamine diphosphate salt |
|---|---|
| Appearance | White solid |
| CAS # | 50-63-5 |
| Molecular Formula | C₁₈H₂₆ClN₃·2H₃PO₄ |
| Molecular Weight | 515.86 |
| Purity | ≥98% by TLC |
| Solubility | H₂O (100 mM) |
| SMILES | CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl.OP(=O)(O)O.OP(=O)(O)O |
| InChi | InChI=1S/C18H26ClN3.2H3O4P/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18;2*1-5(2,3)4/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21);2*(H3,1,2,3,4) |
| InChi Key | QKICWELGRMTQCR-UHFFFAOYSA-N |
| PubChem CID | 64927 |
| MDL Number | MFCD00069852 |
| Handling | Protect from air and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
An antimalarial drug. Inhibits autophagy of glioma cells via a mechanism distinct from that of 3-Methyladenine. It has in vitro activity against several viruses including coronaviruses. It is suspected to act as an inhibitor of acidification within cellular endosomes, thereby interfering with an early post-entry step of virus replication. Hydroxychloroquine may have greater in vitro inhibitory activity than chloroquine.
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Thiele et al., Modified Vaccinia Virus Ankara-Infected Dendritic Cells Present CD4+T-Cell Epitopes by Endogenous Major Histocompatibility Complex Class II Presentation Pathways. J. Virol., Mar 2015; 89: 2698 - 2709.
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