CHIR 99021

A GSK-3β inhibitor
Catalog #: 1677 | abID:

Product Details

Alternate Name 6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile; CT99021
Appearance Off-white solid
CAS # 252917-06-9
Molecular Formula C₂₂H₁₈Cl₂N₈
Molecular Weight 465.34
Purity ≥95% by HPLC
Solubility DMSO ( 100 mM)
InChi InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)
PubChem CID 9956119
MDL Number MFCD12546133
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


A potent and highly selective inhibitor of glycogen synthase kinase-3β (GSK-3β) (IC₅₀ = 6.7 nM). CHIR99021 has been shown to allow for long-term expansion of murine embryonic stem cells in a chemically-defined medium in conjunction with MEK/MAPK inhibitor PD184352 and fibroblast growth factor receptor (FGFR) inhibitor SU5402.

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Shigeharu G. Yabe, Induction of functional islet-like cells from human iPS cells by suspension culture. Regen Ther., Jan. 2019; 30623004.
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